tcplfit2: A Concentration-Response Modeling Utility
Introduction | Suggested packages for use with this vignette | Concentration-Response Modeling | Concentration-Response Modeling for a Single Series with concRespCore | Concentration-Response Modeling for Multiple Series with tcplfit2_core and tcplhit2_core | Concentration-Response Modeling for tcpl-like data without a database connection | - Source Data Formatting | - Adjustments | - Normalization | - Dose-Response Curve Fitting | Hitcalling | - $p_1$: AIC Weight | - $p_2$: Responses Outside Cutoff | - $p_3$: Top Likelihood Ratio | Visual Representation of Proportional Weights | Consideration: Continuous Hitcalls to Activity Calls | Bounding the Benchmark Dose (BMD) | Imposing Lower BMD Bounds | Imposing Upper BMD Bounds | Bounding BMDs with tcplhit2_core | Impacts if BMD is between the BMD Lower Bound and Lowest Dose Tested | Plotting | Plotting All Models with concRespCore and concRespPlot | Plotting All Models with tcplfit2_core Output | Plotting the Winning Model with concRespPlot2 | Customizing concRespPlot2 Plots | - Adding a Plot Title, Shade Cutoff Band, and Potency Estimates | - Label All Potency Estimates | - Add Additional Curves | Area Under the Curve (AUC) | Area Under the Curve (AUC) with concRespCore | Area Under the Curve (AUC) with tcplfit2_core and tcplhit2_core | - Positive Responses | - Negative Responses | - Bi-phasic Responses | Model Details | Polynomial 1 (poly1) | Polynomial 2 (poly2) | Power (pow) | Hill | Gain-Loss (gnls) | Exponential 2 (Exp2) | Exponential 3 (Exp3) | Exponential 4 (Exp4) | Exponential 5 (Exp5) | Table of All Model Details | Glossary