Package: invitroTKstats
Version: 0.0.14
Date: 2026-01-22
Title: In Vitro Toxicokinetic Data Processing and Analysis Pipeline
Description: A set of tools for processing and analyzing in vitro
        toxicokinetic measurements in a standardized and reproducible
        pipeline. The package was developed to perform frequentist and
        Bayesian estimation on a variety of in vitro toxicokinetic
        measurements including -- but not limited to -- chemical
        fraction unbound in the presence of plasma (f_up), intrinsic
        hepatic clearance (Clint, uL/min/million hepatocytes), and
        membrane permeability for oral absorption (Caco2). The methods
        provided by the package were described in Wambaugh et al.
        (2019) <doi:10.1093/toxsci/kfz205>.
Authors@R: c(
           person("John", "Wambaugh", 
             role = c("aut"),comment = c(ORCID = "0000-0002-4024-534X")), 
           person("Caroline", "Ring", email = "ring.caroline@epa.gov",
             role = c("cre"), comment = c(ORCID = "0000-0002-0463-1251")),
           person("Sarah E.", "Davidson-Fritz", email = "davidsonfritz.sarah@epa.gov", 
             role = c("aut"), comment = c(ORCID = "0000-0002-2891-9380")),
           person("Lindsay","Knupp",role = c("ctb")),
           person("Barbara A.","Wetmore",role = c("ctb"),
            comment = c(ORCID = "0000-0002-6878-5348")),
           person("Zhao", "Zhihui", role = c("ctb")),
           person("Chantel", "Nicolas", role = c("ctb"),
             comment = c(ORCID = "0000-0003-2061-5830")),
           person("Anna", "Kreutz", role = c("ctb"),
             comment = c(ORCID = "0000-0002-7787-0683")),
           person("U.S. Federal Government",role = "cph",comment = "Copyright holder of this package")
           )
Depends: R (>= 3.5.0)
Imports: runjags, parallel, readxl, coda, ggplot2, scales, stats4,
        Rdpack, methods, stats, utils, dplyr, rlang
RdMacros: Rdpack
Suggests: knitr, R.rsp, tidyverse, gridExtra, gridtext, flextable,
        rmarkdown, magrittr, stringr
License: MIT + file LICENSE
LazyData: true
Encoding: UTF-8
VignetteBuilder: knitr, R.rsp
RoxygenNote: 7.3.2
NeedsCompilation: no
Maintainer: Caroline Ring <ring.caroline@epa.gov>
URL: https://github.com/USEPA/invitroTKstats
BugReports: https://github.com/USEPA/invitroTKstats/issues
Config/pak/sysreqs: jags
Repository: https://usepa.r-universe.dev
Date/Publication: 2026-02-13 14:26:03 UTC
RemoteUrl: https://github.com/usepa/invitrotkstats
RemoteRef: HEAD
RemoteSha: 43cb092157a85319339361b089c62062cae2a235
Packaged: 2026-06-13 08:13:43 UTC; root
Author: John Wambaugh [aut] (ORCID: <https://orcid.org/0000-0002-4024-534X>),
  Caroline Ring [cre] (ORCID: <https://orcid.org/0000-0002-0463-1251>),
  Sarah E. Davidson-Fritz [aut] (ORCID:
    <https://orcid.org/0000-0002-2891-9380>),
  Lindsay Knupp [ctb],
  Barbara A. Wetmore [ctb] (ORCID:
    <https://orcid.org/0000-0002-6878-5348>),
  Zhao Zhihui [ctb],
  Chantel Nicolas [ctb] (ORCID: <https://orcid.org/0000-0003-2061-5830>),
  Anna Kreutz [ctb] (ORCID: <https://orcid.org/0000-0002-7787-0683>),
  U.S. Federal Government [cph] (Copyright holder of this package)