{"Drug":"Caffeine","DTXSID":"DTXSID0020232","PREFERRED_NAME":"Caffeine","CASRN":"58-08-2","AVERAGE_MASS":194.194,"Dose":150,"Dose Units":"mg","Dosing frequency":"Single dose","Dose.Route":"Oral","Gestational.Age.Weeks":36,"NonPreg.Duration.Days":0.5,"Preg.Duration.Days":1,"Parameter":"AUCinf","Units":"mg/L h","Observed.Non.Pregnant":24.5,"Predicted Non-Pregnant":28.2,"Ratio Non-Pregnant":1.15,"Observed.Pregnant":71,"Predicted Pregnant":60.7,"Ratio Pregnant":0.85,"Mass Conversion":0.001,"Converted Units":"uM h","Observed.Non.Pregnant2":126.1625,"Predicted Non-Pregnant3":145.21561,"Ratio Non-Pregnant4":1.15102,"Observed.Pregnant5":365.61377,"Predicted Pregnant6":312.57402,"Ratio Pregnant7":0.85493,"Predicted.Non.Pregnant.httk":42.48,"Predicted.Pregnant.httk":42.6,"Ratio.obs":2.89796,"Ratio.httk":1.00282}
{"Drug":"Midazolam","DTXSID":"DTXSID5023320","PREFERRED_NAME":"Midazolam","CASRN":"59467-70-8","AVERAGE_MASS":325.77,"Dose":2,"Dose Units":"mg","Dosing frequency":"Single dose","Dose.Route":"Oral","Gestational.Age.Weeks":30,"NonPreg.Duration.Days":0.25,"Preg.Duration.Days":0.25,"Parameter":"AUCinf","Units":"ng/mL h","Observed.Non.Pregnant":17.9,"Predicted Non-Pregnant":17.1,"Ratio Non-Pregnant":0.95,"Observed.Pregnant":9.5,"Predicted Pregnant":7.88,"Ratio Pregnant":0.83,"Mass Conversion":1e-06,"Converted Units":"uM h","Observed.Non.Pregnant2":0.05495,"Predicted Non-Pregnant3":0.05249,"Ratio Non-Pregnant4":0.95531,"Observed.Pregnant5":0.02916,"Predicted Pregnant6":0.02419,"Ratio Pregnant7":0.82947,"Predicted.Non.Pregnant.httk":0.21062,"Predicted.Pregnant.httk":0.16308,"Ratio.obs":0.53073,"Ratio.httk":0.77427}
{"Drug":"Nifedipine","DTXSID":"DTXSID2025715","PREFERRED_NAME":"Nifedipine","CASRN":"21829-25-4","AVERAGE_MASS":346.339,"Dose":20,"Dose Units":"mg","Dosing frequency":"Single dose","Dose.Route":"Oral","Gestational.Age.Weeks":32,"NonPreg.Duration.Days":1,"Preg.Duration.Days":0.33333,"Parameter":"AUCinf","Units":"ng/mL h","Observed.Non.Pregnant":326,"Predicted Non-Pregnant":373,"Ratio Non-Pregnant":1.14,"Observed.Pregnant":272,"Predicted Pregnant":231,"Ratio Pregnant":0.85,"Mass Conversion":1e-06,"Converted Units":"uM h","Observed.Non.Pregnant2":0.94127,"Predicted Non-Pregnant3":1.07698,"Ratio Non-Pregnant4":1.14417,"Observed.Pregnant5":0.78536,"Predicted Pregnant6":0.66698,"Ratio Pregnant7":0.84926,"Predicted.Non.Pregnant.httk":3.0768,"Predicted.Pregnant.httk":1.72968,"Ratio.obs":0.83436,"Ratio.httk":0.56217}
{"Drug":"Metoprolol","DTXSID":"DTXSID2023309","PREFERRED_NAME":"Metoprolol","CASRN":"51384-51-1","AVERAGE_MASS":267.369,"Dose":10,"Dose Units":"mg","Dosing frequency":"Single dose","Dose.Route":"iv","Gestational.Age.Weeks":37,"NonPreg.Duration.Days":0.5,"Preg.Duration.Days":0.5,"Parameter":"AUCinf","Units":"ng/mL h","Observed.Non.Pregnant":256,"Predicted Non-Pregnant":241,"Ratio Non-Pregnant":0.94,"Observed.Pregnant":121,"Predicted Pregnant":132,"Ratio Pregnant":1.09,"Mass Conversion":1e-06,"Converted Units":"uM h","Observed.Non.Pregnant2":0.95748,"Predicted Non-Pregnant3":0.90138,"Ratio Non-Pregnant4":0.94141,"Observed.Pregnant5":0.45256,"Predicted Pregnant6":0.4937,"Ratio Pregnant7":1.09091,"Predicted.Non.Pregnant.httk":0.66384,"Predicted.Pregnant.httk":0.48528,"Ratio.obs":0.47266,"Ratio.httk":0.73102}
{"Drug":"Ondansetron","DTXSID":"DTXSID8023393","PREFERRED_NAME":"Ondansetron","CASRN":"99614-02-5","AVERAGE_MASS":293.37,"Dose":4,"Dose Units":"mg","Dosing frequency":"Single dose","Dose.Route":"iv","Gestational.Age.Weeks":39,"NonPreg.Duration.Days":0.33333,"Preg.Duration.Days":0.33333,"Parameter":"AUCinf","Units":"ng/mL h","Observed.Non.Pregnant":234,"Predicted Non-Pregnant":242,"Ratio Non-Pregnant":1.04,"Observed.Pregnant":164,"Predicted Pregnant":158,"Ratio Pregnant":0.97,"Mass Conversion":1e-06,"Converted Units":"uM h","Observed.Non.Pregnant2":0.79763,"Predicted Non-Pregnant3":0.8249,"Ratio Non-Pregnant4":1.03419,"Observed.Pregnant5":0.55902,"Predicted Pregnant6":0.53857,"Ratio Pregnant7":0.96341,"Predicted.Non.Pregnant.httk":0.61032,"Predicted.Pregnant.httk":0.47112,"Ratio.obs":0.70085,"Ratio.httk":0.77192}
{"Drug":"Granisetron","DTXSID":"DTXSID0023111","PREFERRED_NAME":"Granisetron","CASRN":"109889-09-0","AVERAGE_MASS":312.417,"Dose":1,"Dose Units":"mg","Dosing frequency":"Single dose","Dose.Route":"iv","Gestational.Age.Weeks":15,"NonPreg.Duration.Days":1,"Preg.Duration.Days":1,"Parameter":"AUCinf","Units":"ng/mL h","Observed.Non.Pregnant":125,"Predicted Non-Pregnant":103,"Ratio Non-Pregnant":0.82,"Observed.Pregnant":113,"Predicted Pregnant":111,"Ratio Pregnant":0.98,"Mass Conversion":1e-06,"Converted Units":"uM h","Observed.Non.Pregnant2":0.40011,"Predicted Non-Pregnant3":0.32969,"Ratio Non-Pregnant4":0.824,"Observed.Pregnant5":0.3617,"Predicted Pregnant6":0.35529,"Ratio Pregnant7":0.9823,"Predicted.Non.Pregnant.httk":0.11551,"Predicted.Pregnant.httk":0.09737,"Ratio.obs":0.904,"Ratio.httk":0.84293}
{"Drug":"Diazepam","DTXSID":"DTXSID4020406","PREFERRED_NAME":"Diazepam","CASRN":"439-14-5","AVERAGE_MASS":284.74,"Dose":10,"Dose Units":"mg","Dosing frequency":"Single dose","Dose.Route":"iv","Gestational.Age.Weeks":39,"NonPreg.Duration.Days":1,"Preg.Duration.Days":0.41667,"Parameter":"AUClast","Units":"mg/L h","Observed.Non.Pregnant":2.33,"Predicted Non-Pregnant":2.25,"Ratio Non-Pregnant":0.96,"Observed.Pregnant":0.7,"Predicted Pregnant":0.63,"Ratio Pregnant":0.9,"Mass Conversion":0.001,"Converted Units":"uM h","Observed.Non.Pregnant2":8.1829,"Predicted Non-Pregnant3":7.90195,"Ratio Non-Pregnant4":0.96567,"Observed.Pregnant5":2.45838,"Predicted Pregnant6":2.21254,"Ratio Pregnant7":0.9,"Predicted.Non.Pregnant.httk":16.872,"Predicted.Pregnant.httk":4.6464,"Ratio.obs":0.30043,"Ratio.httk":0.27539}
{"Drug":"Metronidazole","DTXSID":"DTXSID2020892","PREFERRED_NAME":"Metronidazole","CASRN":"443-48-1","AVERAGE_MASS":171.156,"Dose":500,"Dose Units":"mg","Dosing frequency":"Single dose","Dose.Route":"iv","Gestational.Age.Weeks":39,"NonPreg.Duration.Days":2,"Preg.Duration.Days":2,"Parameter":"AUCinf","Units":"mg/L h","Observed.Non.Pregnant":151,"Predicted Non-Pregnant":170,"Ratio Non-Pregnant":1.12,"Observed.Pregnant":102,"Predicted Pregnant":112,"Ratio Pregnant":1.1,"Mass Conversion":0.001,"Converted Units":"uM h","Observed.Non.Pregnant2":882.23609,"Predicted Non-Pregnant3":993.24593,"Ratio Non-Pregnant4":1.12583,"Observed.Pregnant5":595.94756,"Predicted Pregnant6":654.37379,"Ratio Pregnant7":1.09804,"Predicted.Non.Pregnant.httk":102.984,"Predicted.Pregnant.httk":70.944,"Ratio.obs":0.6755,"Ratio.httk":0.68888}
{"Drug":"Acetaminophen","DTXSID":"DTXSID2020006","PREFERRED_NAME":"Acetaminophen","CASRN":"103-90-2","AVERAGE_MASS":151.163,"Dose":2000,"Dose Units":"mg","Dosing frequency":"Single dose","Dose.Route":"iv","Gestational.Age.Weeks":30.9,"NonPreg.Duration.Days":0.25,"Preg.Duration.Days":0.25,"Parameter":"AUCinf","Units":"mg/L h","Observed.Non.Pregnant":101.71,"Observed.Pregnant":74.3,"Mass Conversion":0.001,"Converted Units":"uM h","Observed.Non.Pregnant2":672.84984,"Observed.Pregnant5":491.5224,"Source observed data non-pregnant":"PMID: 31347013","Source observed data pregnant":"PMID: 31347013","Predicted.Non.Pregnant.httk":824.88,"Predicted.Pregnant.httk":551.28,"Ratio.obs":0.73051,"Ratio.httk":0.66832}
{"Drug":"Digoxin","DTXSID":"DTXSID5022934","PREFERRED_NAME":"Digoxin","CASRN":"20830-75-5","AVERAGE_MASS":780.938,"Dose":0.25,"Dose Units":"mg","Dosing frequency":"Single dose","Dose.Route":"Oral","Gestational.Age.Weeks":30.5,"NonPreg.Duration.Days":2,"Preg.Duration.Days":2,"Parameter":"AUClast","Units":"ug/L h","Observed.Non.Pregnant":9.3,"Observed.Pregnant":7.3,"Mass Conversion":1,"Converted Units":"uM h","Observed.Non.Pregnant2":11.90876,"Observed.Pregnant5":9.34773,"Source observed data non-pregnant":"PMID: 18288078","Source observed data pregnant":"PMID: 18288078","Predicted.Non.Pregnant.httk":0.0695,"Predicted.Pregnant.httk":0.04116,"Ratio.obs":0.78495,"Ratio.httk":0.5922}
{"Drug":"Lorazepam","DTXSID":"DTXSID7023225","PREFERRED_NAME":"Lorazepam","CASRN":"846-49-1","AVERAGE_MASS":321.2,"Dose":2,"Dose Units":"mg","Dosing frequency":"Single dose","Dose.Route":"Oral","Gestational.Age.Weeks":38.41,"NonPreg.Duration.Days":1.5,"Preg.Duration.Days":2,"Parameter":"AUCinf","Units":"ug/L h","Observed.Non.Pregnant":560,"Observed.Pregnant":175.25,"Mass Conversion":1,"Converted Units":"uM h","Observed.Non.Pregnant2":1743.46202,"Observed.Pregnant5":545.61021,"Source observed data non-pregnant":"PMID: 6149030","Source observed data pregnant":"PMID: 16143486","Predicted.Non.Pregnant.httk":2.4384,"Predicted.Pregnant.httk":1.82664,"Ratio.obs":0.31295,"Ratio.httk":0.74911}
{"Drug":"Amoxicillin","DTXSID":"DTXSID3037044","PREFERRED_NAME":"Amoxicillin","CASRN":"26787-78-0","AVERAGE_MASS":365.4,"Dose":2000,"Dose Units":"mg","Dosing frequency":"Single dose","Dose.Route":"iv","Gestational.Age.Weeks":35.1,"NonPreg.Duration.Days":0.25,"Preg.Duration.Days":0.16667,"Parameter":"AUCinf","Units":"mg/L h","Observed.Non.Pregnant":103.25279,"Observed.Pregnant":87,"Mass Conversion":0.001,"Converted Units":"uM h","Observed.Non.Pregnant2":282.57468,"Observed.Pregnant5":238.09524,"Source observed data non-pregnant":"PMID: 32748112","Source observed data pregnant":"PMID: 32748112","Predicted.Non.Pregnant.httk":201.84,"Predicted.Pregnant.httk":119.688,"Ratio.obs":0.84259,"Ratio.httk":0.59298}