{"Version":"1.1","N.steadystate":349,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":0.5293,"N.Wetmore":237,"RMSLE.noMC":"0.10929999999999999","N.noMC":237,"RMSLE.InVivoCss":1.869,"N.InVivoCss":30,"RMSLE.InVivoAUC":0.9687,"N.InVivoAUC":53,"RMSLE.InVivoCmax":1.559,"N.InVivoCmax":53}
{"Version":"1.2","N.steadystate":349,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":0.5293,"N.Wetmore":237,"RMSLE.noMC":"0.10929999999999999","N.noMC":237,"RMSLE.InVivoCss":1.869,"N.InVivoCss":30,"RMSLE.InVivoAUC":1.107,"N.InVivoAUC":83,"RMSLE.InVivoCmax":1.437,"N.InVivoCmax":83}
{"Version":"1.3","N.steadystate":543,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":0.6545,"N.Wetmore":398,"RMSLE.noMC":"0.12570000000000001","N.noMC":398,"RMSLE.InVivoCss":1.822,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.094,"N.InVivoAUC":89,"RMSLE.InVivoCmax":1.413,"N.InVivoCmax":89,"RMSLE.TissuePC":0.4612,"N.TissuePC":12}
{"Version":"1.4","N.steadystate":543,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":0.6545,"N.Wetmore":398,"RMSLE.noMC":"0.12570000000000001","N.noMC":398,"RMSLE.InVivoCss":1.822,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.094,"N.InVivoAUC":89,"RMSLE.InVivoCmax":1.413,"N.InVivoCmax":89,"RMSLE.TissuePC":0.4612,"N.TissuePC":12}
{"Version":"1.5","N.steadystate":543,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":0.6833,"N.Wetmore":398,"RMSLE.noMC":"0.16500000000000001","N.noMC":398,"RMSLE.InVivoCss":1.81,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.093,"N.InVivoAUC":87,"RMSLE.InVivoCmax":1.406,"N.InVivoCmax":87,"RMSLE.TissuePC":0.5563,"N.TissuePC":412,"Notes":"HTTK-pop introduced."}
{"Version":"1.6","N.steadystate":553,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":0.823,"N.Wetmore":397,"RMSLE.noMC":"0.45950000000000002","N.noMC":397,"RMSLE.InVivoCss":1.934,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.33,"N.InVivoAUC":87,"RMSLE.InVivoCmax":1.711,"N.InVivoCmax":87,"RMSLE.TissuePC":0.5925,"N.TissuePC":964,"Notes":"Very slow MC sampler"}
{"Version":"1.7","N.steadystate":553,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":0.823,"N.Wetmore":397,"RMSLE.noMC":"0.45950000000000002","N.noMC":397,"RMSLE.InVivoCss":1.934,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.33,"N.InVivoAUC":87,"RMSLE.InVivoCmax":1.711,"N.InVivoCmax":87,"RMSLE.TissuePC":0.5926,"N.TissuePC":964}
{"Version":"1.8","N.steadystate":579,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":0.7937,"N.Wetmore":397,"RMSLE.noMC":"0.41739999999999999","N.noMC":397,"RMSLE.InVivoCss":1.816,"N.InVivoCss":33,"RMSLE.InVivoAUC":1.327,"N.InVivoAUC":89,"RMSLE.InVivoCmax":1.723,"N.InVivoCmax":89,"RMSLE.TissuePC":0.5925,"N.TissuePC":964}
{"Version":"1.9","N.steadystate":587,"calc_analytic.units":10,"calc_mc.units":"10","solve_pbtk.units":1,"RMSLE.Wetmore":0.8947,"N.Wetmore":392,"RMSLE.noMC":"0.4239","N.noMC":392,"RMSLE.InVivoCss":1.871,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.274,"N.InVivoAUC":89,"RMSLE.InVivoCmax":1.697,"N.InVivoCmax":89,"RMSLE.TissuePC":0.6136,"N.TissuePC":953}
{"Version":"1.9.1","N.steadystate":587,"calc_analytic.units":1,"calc_mc.units":"NA","solve_pbtk.units":1,"RMSLE.Wetmore":2,"N.Wetmore":0,"RMSLE.noMC":"NaN","N.noMC":0,"RMSLE.InVivoCss":1.787,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.274,"N.InVivoAUC":89,"RMSLE.InVivoCmax":1.697,"N.InVivoCmax":89,"RMSLE.TissuePC":0.6136,"N.TissuePC":953,"Notes":"calc_mc_css non-functional, NA values replaced with \"2\""}
{"Version":"1.9.2","N.steadystate":583,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":0.805,"N.Wetmore":392,"RMSLE.noMC":"0.47589999999999999","N.noMC":392,"RMSLE.InVivoCss":1.787,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.274,"N.InVivoAUC":89,"RMSLE.InVivoCmax":1.697,"N.InVivoCmax":89,"RMSLE.TissuePC":0.6136,"N.TissuePC":953}
{"Version":"1.10.0","N.steadystate":944,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":1.127,"N.Wetmore":401,"RMSLE.noMC":"0.3095","N.noMC":401,"RMSLE.InVivoCss":1.873,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.284,"N.InVivoAUC":85,"RMSLE.InVivoCmax":1.7,"N.InVivoCmax":85,"RMSLE.TissuePC":0.6115,"N.TissuePC":964,"Notes":"Increased estimated uncertainty on in vitro data. New in vitro numbers for some chemicals,"}
{"Version":"1.10.1","N.steadystate":944,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":1.127,"N.Wetmore":402,"RMSLE.noMC":"0.3095","N.noMC":401,"RMSLE.InVivoCss":1.873,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.284,"N.InVivoAUC":85,"RMSLE.InVivoCmax":1.7,"N.InVivoCmax":85,"RMSLE.TissuePC":0.6115,"N.TissuePC":964}
{"Version":"2.0.0","N.steadystate":987,"calc_analytic.units":0.9997,"calc_mc.units":"1","solve_pbtk.units":0.9997,"RMSLE.Wetmore":1.121,"N.Wetmore":397,"RMSLE.noMC":"0.315","N.noMC":397,"RMSLE.InVivoCss":1.89,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.278,"N.InVivoAUC":83,"RMSLE.InVivoCmax":1.179,"N.InVivoCmax":83,"RMSLE.TissuePC":0.6098,"N.TissuePC":858,"Notes":"Refactored Monte Carlo functions, likely broke calc_ionization for monte carlo."}
{"Version":"2.0.1","N.steadystate":987,"calc_analytic.units":0.9997,"calc_mc.units":"0.99960000000000004","solve_pbtk.units":0.9997,"RMSLE.Wetmore":1.163,"N.Wetmore":401,"RMSLE.noMC":"0.32329999999999998","N.noMC":401,"RMSLE.InVivoCss":1.914,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.277,"N.InVivoAUC":83,"RMSLE.InVivoCmax":1.188,"N.InVivoCmax":83,"RMSLE.TissuePC":0.7611,"N.TissuePC":858}
{"Version":"2.0.2","N.steadystate":987,"calc_analytic.units":0.9997,"calc_mc.units":"0.99960000000000004","solve_pbtk.units":0.9997,"RMSLE.Wetmore":1.163,"N.Wetmore":401,"RMSLE.noMC":"0.32329999999999998","N.noMC":401,"RMSLE.InVivoCss":1.914,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.277,"N.InVivoAUC":83,"RMSLE.InVivoCmax":1.188,"N.InVivoCmax":83,"RMSLE.TissuePC":0.7611,"N.TissuePC":858}
{"Version":"2.0.3","N.steadystate":1016,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":0.9999,"RMSLE.Wetmore":1.154,"N.Wetmore":401,"RMSLE.noMC":"0.3241","N.noMC":401,"RMSLE.InVivoCss":1.927,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.336,"N.InVivoAUC":90,"RMSLE.InVivoCmax":1.245,"N.InVivoCmax":90,"RMSLE.TissuePC":0.7854,"N.TissuePC":851}
{"Version":"2.0.4","N.steadystate":998,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":0.9999,"RMSLE.Wetmore":1.166,"N.Wetmore":398,"RMSLE.noMC":"0.32500000000000001","N.noMC":398,"RMSLE.InVivoCss":1.791,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.28,"N.InVivoAUC":90,"RMSLE.InVivoCmax":1.228,"N.InVivoCmax":90,"RMSLE.TissuePC":0.7866,"N.TissuePC":840}
{"Version":"2.1.0","N.steadystate":943,"calc_analytic.units":1,"calc_mc.units":"4.38","solve_pbtk.units":0.9998,"RMSLE.Wetmore":0.9059,"N.Wetmore":371,"RMSLE.noMC":"0.34410000000000002","N.noMC":371,"RMSLE.InVivoCss":1.782,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.274,"N.InVivoAUC":88,"RMSLE.InVivoCmax":1.21,"N.InVivoCmax":88,"RMSLE.TissuePC":0.5995,"N.TissuePC":863,"Notes":"uM units on `calc_mc_css` were incorrectly calculated. Fixed bug that caused ionization to be ignored. Chemicals dropped based on PFC's, volatility."}
{"Version":"2.2.0","N.steadystate":941,"calc_analytic.units":0.9999,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":1.114,"N.Wetmore":370,"RMSLE.noMC":"0.33710000000000001","N.noMC":370,"RMSLE.InVivoCss":1.682,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.162,"N.InVivoAUC":88,"RMSLE.InVivoCmax":1.118,"N.InVivoCmax":88,"RMSLE.TissuePC":0.6428,"N.TissuePC":863,"Notes":"Monte Carlo bug fixes."}
{"Version":"2.2.1","N.steadystate":941,"calc_analytic.units":0.9999,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":1.114,"N.Wetmore":370,"RMSLE.noMC":"0.33710000000000001","N.noMC":370,"RMSLE.InVivoCss":1.682,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.162,"N.InVivoAUC":88,"RMSLE.InVivoCmax":1.118,"N.InVivoCmax":88,"RMSLE.TissuePC":0.643,"N.TissuePC":863}
{"Version":"2.2.2","N.steadystate":941,"calc_analytic.units":0.9997,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":1.087,"N.Wetmore":370,"RMSLE.noMC":"0.24709999999999999","N.noMC":370,"RMSLE.InVivoCss":1.979,"N.InVivoCss":31,"RMSLE.InVivoAUC":1.379,"N.InVivoAUC":88,"RMSLE.InVivoCmax":1.248,"N.InVivoCmax":88,"RMSLE.TissuePC":0.63,"N.TissuePC":863,"Notes":"Fixed bug that caused calc_ionization to be inaccurate for monte carlo. Removed extra Kilford hepatic binding correction. Fixed steady-state functions returning blood instead of plasma."}
{"Version":"2.3.0","N.steadystate":1023,"calc_analytic.units":0.9999,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":1.063,"N.Wetmore":352,"RMSLE.noMC":"0.29959999999999998","N.noMC":352,"RMSLE.InVivoCss":1.419,"N.InVivoCss":29,"RMSLE.InVivoAUC":1.047,"N.InVivoAUC":86,"RMSLE.InVivoCmax":1.33,"N.InVivoCmax":86,"RMSLE.TissuePC":0.6344,"N.TissuePC":863,"Notes":"Used Caco-2 to replace Fabs=Fgut=1"}
{"Version":"2.3.1","N.steadystate":1023,"calc_analytic.units":0.9999,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":1.011,"N.Wetmore":352,"RMSLE.noMC":"0.29049999999999998","N.noMC":352,"RMSLE.InVivoCss":1.478,"N.InVivoCss":29,"RMSLE.InVivoAUC":1.102,"N.InVivoAUC":86,"RMSLE.InVivoCmax":1.376,"N.InVivoCmax":86,"RMSLE.TissuePC":0.6344,"N.TissuePC":863}
{"Version":"2.4.0","N.steadystate":1021,"calc_analytic.units":1,"calc_mc.units":"1","solve_pbtk.units":1,"RMSLE.Wetmore":0.9477,"N.Wetmore":353,"RMSLE.noMC":"0.27160000000000001","N.noMC":353,"RMSLE.InVivoCss":1.508,"N.InVivoCss":36,"RMSLE.InVivoAUC":0.9698,"N.InVivoAUC":80,"RMSLE.InVivoCmax":1.132,"N.InVivoCmax":80,"RMSLE.TissuePC":0.6466,"N.TissuePC":863,"Notes":"Switched to chem props from ctxR"}