{"Reference":"Jia 2003","Species":"rat","Compound":"Carbendazim","CAS":"10605-21-7","Route":"po","dose":1000,"dose.units":"mg/kg","time":20,"time.units":"h","AUC":128.86632,"AUC.units":"mg*h/L","Cmax":17.46065,"Cmax.units":"mg/L","AUC.pred":12.58983,"Cmax.pred":130.09148}
{"Reference":"Aanderud 1983","Species":"rat","Compound":"Antipyrine","CAS":"60-80-0","Route":"iv","dose":15,"dose.units":"mg/kg","time":4,"time.units":"h","AUC":19.8478,"AUC.units":"mg*h/L","Cmax":9.83278,"Cmax.units":"mg/L","AUC.pred":1.04975,"Cmax.pred":14.36589}
{"Reference":"Wang 1999","Species":"rat","Compound":"Alprazolam","CAS":"28981-97-7","Route":"iv","dose":1.2,"dose.units":"mg/kg","time":2,"time.units":"h","AUC":0.15407,"AUC.units":"mg*h/L","Cmax":0.7912,"Cmax.units":"mg/L","Fbio":0.35386,"AUC.pred":0.02839,"Cmax.pred":0.61336,"AUC.pred.Fbio":0.02839,"Cmax.pred.Fbio":0.61336}
{"Reference":"Wang 1999","Species":"rat","Compound":"Alprazolam","CAS":"28981-97-7","Route":"po","dose":7,"dose.units":"mg/kg","time":6,"time.units":"h","AUC":0.23488,"AUC.units":"mg*h/L","Cmax":0.09152,"Cmax.units":"mg/L","Fbio":0.35386,"AUC.pred":0.09911,"Cmax.pred":0.7382,"AUC.pred.Fbio":0.03507,"Cmax.pred.Fbio":0.26122}
{"Reference":"Wang 1999","Species":"rat","Compound":"Alprazolam","CAS":"28981-97-7","Route":"po","dose":12.5,"dose.units":"mg/kg","time":6,"time.units":"h","AUC":0.59939,"AUC.units":"mg*h/L","Cmax":0.20679,"Cmax.units":"mg/L","Fbio":0.35386,"AUC.pred":0.17699,"Cmax.pred":1.31821,"AUC.pred.Fbio":0.06263,"Cmax.pred.Fbio":0.46647}
{"Reference":"Treiber 2004","Species":"rat","Compound":"Bosentan","CAS":"147536-97-8","Route":"iv","dose":1,"dose.units":"mg/kg","time":8,"time.units":"h","AUC":0.6756,"AUC.units":"mg*h/L","Cmax":1.94796,"Cmax.units":"mg/L","Fbio":0.40735,"AUC.pred":0.07879,"Cmax.pred":0.25026,"AUC.pred.Fbio":0.07879,"Cmax.pred.Fbio":0.25026}
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{"Reference":"Leon-Reyes 2009","Species":"rat","Compound":"Diclofenac","CAS":"15307-86-5","Route":"po","dose":18,"dose.units":"mg/kg","time":8,"time.units":"h","AUC":23.42601,"AUC.units":"mg*h/L","Cmax":9.33351,"Cmax.units":"mg/L","AUC.pred":0.92736,"Cmax.pred":3.45741}
{"Reference":"Tsui 1994","Species":"rat","Compound":"Diltiazem","CAS":"42399-41-7","Route":"iv","dose":20,"dose.units":"mg/kg","time":10,"time.units":"h","AUC":8.04371,"AUC.units":"mg*h/L","Cmax":7.8672,"Cmax.units":"mg/L","Fbio":0.17086,"AUC.pred":2.10267,"Cmax.pred":8.83466,"AUC.pred.Fbio":2.10267,"Cmax.pred.Fbio":8.83466}
{"Reference":"Tsui 1994","Species":"rat","Compound":"Diltiazem","CAS":"42399-41-7","Route":"po","dose":20,"dose.units":"mg/kg","time":6,"time.units":"h","AUC":1.16704,"AUC.units":"mg*h/L","Cmax":1.22225,"Cmax.units":"mg/L","Fbio":0.17086,"AUC.pred":1.23963,"Cmax.pred":5.99403,"AUC.pred.Fbio":0.21181,"Cmax.pred.Fbio":1.02415}
{"Reference":"Igari 1982","Species":"rat","Compound":"Hexobarbitone","CAS":"56-29-1","Route":"iv","dose":60,"dose.units":"mg/kg","time":1.5,"time.units":"h","AUC":60.35748,"AUC.units":"mg*h/L","Cmax":128.63252,"Cmax.units":"mg/L","AUC.pred":1.36018,"Cmax.pred":80.77651}
{"Reference":"Satterwhite 1991","Species":"rat","Compound":"Ibuprofen","CAS":"15687-27-1","Route":"iv","dose":2.5,"dose.units":"mg/kg","time":16.14,"time.units":"h","AUC":16.56568,"AUC.units":"mg*h/L","Cmax":7.86032,"Cmax.units":"mg/L","AUC.pred":1.96723,"Cmax.pred":4.17504}
{"Reference":"Satterwhite 1991","Species":"rat","Compound":"Ibuprofen","CAS":"15687-27-1","Route":"iv","dose":25,"dose.units":"mg/kg","time":15.69,"time.units":"h","AUC":125.95933,"AUC.units":"mg*h/L","Cmax":90.0285,"Cmax.units":"mg/L","AUC.pred":19.25225,"Cmax.pred":41.75042}
{"Reference":"Szymura 1983","Species":"rat","Compound":"Imipramine","CAS":"50-49-7","Route":"iv","dose":10,"dose.units":"mg/kg","time":4,"time.units":"h","AUC":1.8909,"AUC.units":"mg*h/L","Cmax":2.34437,"Cmax.units":"mg/L","Fbio":0.2592,"AUC.pred":0.14889,"Cmax.pred":1.19047,"AUC.pred.Fbio":0.14889,"Cmax.pred.Fbio":1.19047}
{"Reference":"Okiyama 1988","Species":"rat","Compound":"Imipramine","CAS":"50-49-7","Route":"po","dose":50,"dose.units":"mg/kg","time":24,"time.units":"h","AUC":1.05537,"AUC.units":"mg*h/L","Cmax":0.0991,"Cmax.units":"mg/L","Fbio":0.2592,"AUC.pred":1.18313,"Cmax.pred":3.16505,"AUC.pred.Fbio":0.30667,"Cmax.pred.Fbio":0.8204}
{"Reference":"Boralli 2005","Species":"rat","Compound":"Metoprolol","CAS":"51384-51-1","Route":"po","dose":15,"dose.units":"mg/kg","time":4,"time.units":"h","AUC":0.09036,"AUC.units":"mg*h/L","Cmax":0.30581,"Cmax.units":"mg/L","AUC.pred":0.09253,"Cmax.pred":0.77648}
{"Reference":"Kotegawa 2002","Species":"rat","Compound":"Midazolam","CAS":"59467-70-8","Route":"iv","dose":5,"dose.units":"mg/kg","time":4,"time.units":"h","AUC":0.9941,"AUC.units":"mg*h/L","Cmax":2.21223,"Cmax.units":"mg/L","Fbio":0.11051,"AUC.pred":0.21707,"Cmax.pred":3.36991,"AUC.pred.Fbio":0.21707,"Cmax.pred.Fbio":3.36991}
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{"Reference":"Tokuma 1988","Species":"rat","Compound":"Nilvadipine","CAS":"75530-68-6","Route":"iv","dose":0.1,"dose.units":"mg/kg","time":6,"time.units":"h","AUC":0.01882,"AUC.units":"mg*h/L","Cmax":0.0283,"Cmax.units":"mg/L","Fbio":0.15021,"AUC.pred":0.00269,"Cmax.pred":0.33562,"AUC.pred.Fbio":0.00269,"Cmax.pred.Fbio":0.33562}
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{"Reference":"Yang 2008","Species":"rat","Compound":"Ondansetron","CAS":"99614-02-5","Route":"iv","dose":4,"dose.units":"mg/kg","time":2,"time.units":"h","AUC":1.97801,"AUC.units":"mg*h/L","Cmax":37.11163,"Cmax.units":"mg/L","Fbio":0.09834,"AUC.pred":0.15683,"Cmax.pred":2.0313,"AUC.pred.Fbio":0.15683,"Cmax.pred.Fbio":2.0313}
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{"Reference":"Yang 2008","Species":"rat","Compound":"Ondansetron","CAS":"99614-02-5","Route":"iv","dose":20,"dose.units":"mg/kg","time":4,"time.units":"h","AUC":11.04303,"AUC.units":"mg*h/L","Cmax":174.64252,"Cmax.units":"mg/L","Fbio":0.09834,"AUC.pred":1.45593,"Cmax.pred":10.15648,"AUC.pred.Fbio":1.45593,"Cmax.pred.Fbio":10.15648}
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{"Reference":"Cruz 2002","Species":"rat","Compound":"Phenacetin","CAS":"62-44-2","Route":"iv","dose":23,"dose.units":"mg/kg","time":2,"time.units":"h","AUC":23.00322,"AUC.units":"mg*h/L","Cmax":26.2802,"Cmax.units":"mg/L","AUC.pred":0.75181,"Cmax.pred":19.90302}
{"Reference":"Wang 2010","Species":"rat","Compound":"Tolbutamide","CAS":"64-77-7","Route":"iv","dose":10,"dose.units":"mg/kg","time":6,"time.units":"h","AUC":196.66669,"AUC.units":"mg*h/L","Cmax":64.1638,"Cmax.units":"mg/L","Fbio":0.99995,"AUC.pred":2.28288,"Cmax.pred":29.28893,"AUC.pred.Fbio":2.28288,"Cmax.pred.Fbio":29.28893}
{"Reference":"Nagata 2007","Species":"rat","Compound":"Tolbutamide","CAS":"64-77-7","Route":"po","dose":20,"dose.units":"mg/kg","time":12,"time.units":"h","AUC":533.55097,"AUC.units":"mg*h/L","Cmax":85.3125,"Cmax.units":"mg/L","Fbio":0.99995,"AUC.pred":4.54829,"Cmax.pred":27.62455,"AUC.pred.Fbio":4.54805,"Cmax.pred.Fbio":27.62312}
{"Reference":"Della Paschoa 1998","Species":"rat","Compound":"Phenytoin","CAS":"57-41-0","Route":"iv","dose":40,"dose.units":"mg/kg","time":4,"time.units":"h","AUC":46.4687,"AUC.units":"mg*h/L","Cmax":54.26627,"Cmax.units":"mg/L","Fbio":0.29618,"AUC.pred":5.36474,"Cmax.pred":61.05502,"AUC.pred.Fbio":5.36474,"Cmax.pred.Fbio":61.05502}
{"Reference":"Kim 2008","Species":"rat","Compound":"Phenytoin","CAS":"57-41-0","Route":"iv","dose":25,"dose.units":"mg/kg","time":4,"time.units":"h","AUC":212.95898,"AUC.units":"mg*h/L","Cmax":460.69129,"Cmax.units":"mg/L","Fbio":0.29618,"AUC.pred":3.35297,"Cmax.pred":38.15939,"AUC.pred.Fbio":3.35297,"Cmax.pred.Fbio":38.15939}
{"Reference":"Kim 2008","Species":"rat","Compound":"Phenytoin","CAS":"57-41-0","Route":"po","dose":25,"dose.units":"mg/kg","time":12,"time.units":"h","AUC":13.12986,"AUC.units":"mg*h/L","Cmax":4.11735,"Cmax.units":"mg/L","Fbio":0.29618,"AUC.pred":3.9523,"Cmax.pred":19.70516,"AUC.pred.Fbio":1.17057,"Cmax.pred.Fbio":5.83618}
{"Reference":"Timchalk 2002","Species":"rat","Compound":"Chlorpyrifos","CAS":"2921-88-2","Route":"po","dose":5,"dose.units":"mg/kg","time":12,"time.units":"h","AUC":0.14238,"AUC.units":"mg*h/L","Cmax":0.02158,"Cmax.units":"mg/L","AUC.pred":0.77623,"Cmax.pred":1.69608}
{"Reference":"Timchalk 2002","Species":"rat","Compound":"Chlorpyrifos","CAS":"2921-88-2","Route":"po","dose":10,"dose.units":"mg/kg","time":12,"time.units":"h","AUC":0.37246,"AUC.units":"mg*h/L","Cmax":0.06395,"Cmax.units":"mg/L","AUC.pred":1.55247,"Cmax.pred":3.39217}
{"Reference":"Timchalk 2002","Species":"rat","Compound":"Chlorpyrifos","CAS":"2921-88-2","Route":"po","dose":50,"dose.units":"mg/kg","time":12,"time.units":"h","AUC":1.28725,"AUC.units":"mg*h/L","Cmax":0.20268,"Cmax.units":"mg/L","AUC.pred":7.76235,"Cmax.pred":16.96083}
{"Reference":"Timchalk 2002","Species":"rat","Compound":"Chlorpyrifos","CAS":"2921-88-2","Route":"po","dose":100,"dose.units":"mg/kg","time":12,"time.units":"h","AUC":3.97024,"AUC.units":"mg*h/L","Cmax":0.50255,"Cmax.units":"mg/L","AUC.pred":15.52469,"Cmax.pred":33.92165}
{"Reference":"Kawai 1998","Species":"rat","Compound":"Cyclosporin A","CAS":"59865-13-3","Route":"iv","dose":5.9,"dose.units":"mg/kg","time":32,"time.units":"h","AUC":31.24919,"AUC.units":"mg*h/L","Cmax":17.04316,"Cmax.units":"mg/L","AUC.pred":2.03793,"Cmax.pred":4.35488}
{"Reference":"Tanaka 2000","Species":"rat","Compound":"Cyclosporin A","CAS":"59865-13-3","Route":"iv","dose":6,"dose.units":"mg/kg","time":18,"time.units":"h","AUC":27.16786,"AUC.units":"mg*h/L","Cmax":14.75673,"Cmax.units":"mg/L","AUC.pred":1.72736,"Cmax.pred":4.4287}
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{"Reference":"Binkerd 1988","Species":"rat","Compound":"Valproic acid","CAS":"99-66-1","Route":"po","dose":600,"dose.units":"mg/kg","time":4,"time.units":"h","AUC":2299.06008,"AUC.units":"mg*h/L","Cmax":797.9394,"Cmax.units":"mg/L","Fbio":0.99905,"AUC.pred":125.4986,"Cmax.pred":935.12342,"AUC.pred.Fbio":125.37952,"Cmax.pred.Fbio":934.23616}
{"Reference":"Kobayashi 1991","Species":"rat","Compound":"Valproic acid","CAS":"99-66-1","Route":"iv","dose":10,"dose.units":"mg/kg","time":4,"time.units":"h","AUC":24.01852,"AUC.units":"mg*h/L","Cmax":69.905,"Cmax.units":"mg/L","Fbio":0.99905,"AUC.pred":2.52747,"Cmax.pred":26.25028,"AUC.pred.Fbio":2.52747,"Cmax.pred.Fbio":26.25028}
{"Reference":"Kobayashi 1991","Species":"rat","Compound":"Valproic acid","CAS":"99-66-1","Route":"iv","dose":50,"dose.units":"mg/kg","time":4,"time.units":"h","AUC":158.62117,"AUC.units":"mg*h/L","Cmax":290.001,"Cmax.units":"mg/L","Fbio":0.99905,"AUC.pred":12.63734,"Cmax.pred":131.25138,"AUC.pred.Fbio":12.63734,"Cmax.pred.Fbio":131.25138}
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{"Reference":"RTI 2015","Species":"rat","Compound":"Bensulide","CAS":"741-58-2","Route":"po","dose":5.09041,"dose.units":"mg/kg","time":24,"time.units":"h","AUC":0.01449,"AUC.units":"mg*h/L","Cmax":0.00572,"Cmax.units":"mg/L","AUC.pred":1.81337,"Cmax.pred":7.78847}
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